RNA-mediated toxicity in neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
RNA metabolism in neurodegenerative disease
Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered ...
متن کاملTau oligomers and tau toxicity in neurodegenerative disease.
AD (Alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. Although there is much evidence linking tau to neurodegeneration, the precise mechanism of tau-mediated neurotoxicity remains elusive. The presence of tau-positive pre-tangle neurons lacking neurofibrillary tangles h...
متن کاملRectifying RNA splicing errors in hereditary neurodegenerative disease.
The normal pattern of human gene expression requires precise coordination between the transcriptional and RNA processing machineries (1). During and following transcription, nascent RNAs may be modified by 5′-end capping, splicing, and 3′-end cleavage/ polyadenylation to generate the vast repertoire of gene products required for proper gene expression, from embryonic to late adult life. RNA spl...
متن کاملTOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease
Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also enhance cell death, and the TOR inhibitor rapamycin protects cells against proapoptotic stimuli. Autophagy, which can protect against cell death, is negatively regulated by TOR, and disruption of autophagy by mutation of Atg5 or Atg7 can lead to neurodegeneration. However, the implied functional connection ...
متن کاملSublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological consequences of free radical damage. In fact, because it is largely single-stranded and its bases lack the protection of hydrogen bonding and binding by specific proteins, RNA may be more susceptible to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2013
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2012.12.006